On April 16, 2025, over 300 undergraduate students shared their research and achievements through oral presentations, poster presentations, artistic exhibits, performances, films, interactive games, and more in the University Center.

Congratulations to all CBEE students who participated in the event!

Oral Presentations

Evalynn Ellison | Ultrasound-Responsive Phospholipid-Coated Microbubbles for Controlled Drug Delivery Across Mucosa | Chemical, Biochemical, and Environmental Engineering | Canan Dagdeviren

Poster Presentations

Shashane Anderson | Formal Verification of Thermodynamic Models With Lean 4 | Chemical, Biochemical, and Environmental Engineering | Tyler Josephson

Alvin Bett | Detecting PFAS in Baltimore Harbor Using Novel Passive Samplers | Chemical, Biochemical, and Environmental Engineering | Lee Blaney

Jacob Craft | Measuring the Selectivity Coefficients of 19 PFAS With Four Anion-Exchange Membranes | Chemical, Biochemical, and Environmental Engineering | Lee Blaney

Joshua Dayie | Engineering CRBN for Improved Assay and Structural Enablement Using DeNovo Protein Scaffolds | Chemical, Biochemical, and Environmental Engineering | Nicole LaRonde

Trevor Gibson | Hybrid Anion-Exchange Resins Improve the Uptake and Selectivity for (Ultra)Short-Chain PFAS in Drinking Water | Chemical, Biochemical, and Environmental Engineering | Lee Blaney

Elias Gilotte | Uncovering The Relationship Between Oxygen Availability and Energy Sources in Cell-free Protein Synthesis | Chemical, Biochemical, and Environmental Engineering | Govind Rao

Alexander Haibel | GraphARC: An AI Benchmark for Chemical Reasoning | Chemical, Biochemical, and Environmental Engineering | Tyler Josephson

Sydney Hofstetter | Sucrose Density Gradient Centrifugation Versus Anion Exchange for Exosome Sample Purification | Chemical, Biochemical, and Environmental Engineering | Jorge Almodovar

Jasmine Ives | Polychlorinated Biphenyl Monitoring in Maryland Fish | Chemical, Biochemical, and Environmental Engineering | Upal Ghosh

Tonderai Kodzwa | Effect Of Temperature On Aqueous Zinc Ion Batteries | Chemical, Biochemical, and Environmental Engineering | Ozgur Capraz

Peter Lombardo | Percent Viability Screens To Confirm Integral Cell Wall Signaling Kinases In Aspergillus Nidulans | Chemical, Biochemical, and Environmental Engineering | Mark Marten

Terra Miley | Optimization Of Cell-Free Protein Synthesis Bioreactors With the Use of a Fluorescent Magnesium Biosensor | Chemical, Biochemical, and Environmental Engineering | Govind Rao

Meredith Morse | Characterizing The Aspergillus Nidulans Kinase Deletion Library | Chemical, Biochemical, and Environmental Engineering | Mark Marten

Tithi Prajapati | Noninvasive Wearable Device For Transcutaneous CO2 Based Early Detection Of Opioid-Induced Respiratory Depression | Chemical, Biochemical, and Environmental Engineering | Venkatesh Srinivasan

Matthew Quintanilla | Characterization Of Transmembrane Transporters Linked To Cell Wall Stress Response | Chemical, Biochemical, and Environmental Engineering | Mark Marten

Jessica Slaughter | Suite Of Bioinformatic-Analysis Apps For Better Understanding Dynamic Omics Data | Chemical, Biochemical, and Environmental Engineering | Mark Marten

Maaike Swaters | Measuring Ion-exchange Membrane Properties That Control Nutrient Recovery By Donnan Dialysis | Chemical, Biochemical, and Environmental Engineering | Lee Blaney

Greeshma Tarimala | Using Gene Editing And Fluorescent Microscopy To Characterize The PrkA Kinase In Aspergillus Nidulans | Chemical, Biochemical, and Environmental Engineering | Mark Marten

Julia Van Der Marel | Monitoring Of NADH Concentrations In Cell-Free Systems | Chemical, Biochemical, and Environmental Engineering | Govind Rao

Benjamin Welling | Fabrications Of An Autonomous Chemically Powered Vehicle: (AIChE Chem-E Car) | Chemical, Biochemical, and Environmental Engineering | Neha Raikar

Zorah Williams | Utilizing Manganese-Oxide As An Electrode Material For Aqueous Zn-ion Batteries. | Chemical, Biochemical, and Environmental Engineering | Ozgur Capraz

Ariel Wilson-Gray | Production Of Extracellular Vesicles From Mammalian Cells Modulated By A Biomimetic Surface | Chemical, Biochemical, and Environmental Engineering | Jorge Almodovar

Reposted from UMBC News: https://umbc.edu/quick-posts/umbc-delegates-conference-in-india/

Photo credit: The UMBC team of (left to right) Ramana Vinjamuri, Anupam Joshi, Upal Ghosh, Karuna Pande Joshi, Govind Rao, and David Di Maria at the PIWOT conference. (Photo courtesy of Karuna Joshi)

A six-person UMBC team built international connections at the “PIWOT – World of Technology” conference, held in late January in Mumbai, India. The conference is organized by the alumni association for graduates of the prestigious Indian Institutes of Technology (IITs), and attracts many of the leaders in science and technology in India and around the world. The CEO of Alphabet, Inc. (Google’s parent company), the co-founder of Sun Microsystems, and the CEO of IBM are all graduates of IITs. 

UMBC was represented at the conference by Anupam Joshi, acting dean of the College of Engineering and Information Technology; Upal Ghosh, professor in the Department of Chemical, Biochemical and Environmental Engineering; Ramana Vinjamuri, associate professor in the Department of Computer Science and Electrical Engineering and director of the NSF IUCRC BRAIN Center; Govind Rao, director of the Center for Advanced Sensor Technology and professor in the Department of Chemical, Biochemical and Environmental Engineering; Karuna Pande Joshi, professor in the Department of Information Systems and director of the NSF IUCRC Center for Accelerated Real Time Analytics; and David Di Maria, senior international officer and associate vice provost for international education at UMBC. 

Dean Joshi spoke at the conference about the impact of technology on education. (Photo courtesy of Govind Rao)

The UMBC team staffed a well-trafficked booth in the Expo Hall. As an extension of the meeting, they also visited IITs at Mumbai, Hyderabad, and Tirupati, and met with the directors of these institutions to discuss institutional agreements and lay the groundwork for international faculty and student exchanges. 

This year’s PIWOT conference focused on the impact of technology across multiple dimensions of life, from the professional to the personal. Dean Joshi took part as a speaker on a panel about the impact of technology on education. The UMBC booth also displayed the low-cost infant incubator developed by Professor Govind Rao

The UMBC booth displayed the low-cost infant incubator developed by Professor Govind Rao. (Photo courtesy of Karuna Joshi)

Authors: 

Zach Sheffield, Priyanka Paul, Shraddha Krishnakumar, Dipanjan Pan

Title: 

Current Strategies and Future Directions of Wearable Biosensors for Measuring Stress Biochemical Markers for Neuropsychiatric Applications

Abstract:

Most wearable biosensors aimed at capturing psychological state target stress biomarkers in the form of physical symptoms that can correlate with dysfunction in the central nervous system (CNS). However, such markers lack the specificity needed for diagnostic or preventative applications. Wearable biochemical sensors (WBSs) have the potential to fill this gap, however, the technology is still in its infancy. Most WBSs proposed thus far target cortisol. Although cortisol detection is demonstrated as a viable method for approximating the extent and severity of psychological stress, the hormone also lacks specificity. Multiplex WBSs that simultaneously target cortisol alongside other viable stress-related biochemical markers (SBMs) can prove to be indispensable for understanding how psychological stress contributes to the pathophysiology of neuropsychiatric illnesses (NPIs) and, thus, lead to the discovery of new biomarkers and more objective clinical tools. However, none target more than one SBM implicated in NPIs. Till this review, cortisol's connection to dysfunctions in the CNS, to other SBMs, and their implication in various NPIs has not been discussed in the context of developing WBS technology. As such, this review is meant to inform the biosensing and neuropsychiatric communities of viable future directions and possible challenges for WBS technology for neuropsychiatric applications.

full article: https://doi.org/10.1002/advs.20241133

Vida Rahmatnejad, 'M.S. Chemical and Biochemical EngineeringPh.D. '23 Chemical and Biochemical Engineering with Michael Tolosa, Xudong Ge & Govind Rao have a new paper, published in the Biotechnology Letters. The title of the paper is: "Completely noninvasive multi-analyte monitoring system for cell culture processes".

Publication is available here

CBEE hosted the 2024 CBEE Graduate Student Awards on Friday, August 30, 2024 where graduate students were formally recognized for their research and leadership. During the awards ceremony, each awardee gave a 10-minute presentation on their current research. 

Congratulations to the award recipients. 

Excellence in Master's Research

Margaret Siao

’23, M.S. student, Environmental Engineering

Advisor: Dr. Lee Blaney

This award recognizes a CBEE Master’s Student for outstanding performance in research.

Excellence in Doctoral Research

Chad Sundberg

Ph.D. student, Environmental Engineering

Advisor: Dr. Govind Rao

This award recognizes a CBEE Doctoral Student for outstanding performance in research. 

Excellence in Leadership

Alex Doan

Ph.D. student, Chemical and Biochemical Engineering

This award recognizes a CBEE Graduate Student for outstanding leadership demonstrated in service to the department, college, or their fellow students.

Award recipients were nominated by CBEE faculty, staff, or students (graduate or undergraduate). The nominations were reviewed and selected by CBEE’s Graduate program Committee. 

The College of Engineering and Information Technology (COEIT) Research Day was held on April 19, 2024. Undergraduate and graduate students across the college presented their research covering a range of topics.

Congratulations to the CBEE students who received COEIT Research Day Poster Awards. Poster presenters are in bold. 

Bachelor Student Poster Awards

Authors: Tithi Prajapati, Mike Tolosa, Venkatesh Srinivasan, and Dr. Govind Rao
Department: Chemical, Biochemical and Environmental Engineering
Poster Title: Affordable Hand-held Portable Spectroscopy Technology for PAT applications

Authors: Mesha Shajahan, Preety Ahuja, and Dr. Govind Rao
Department: Chemical, Biochemical and Environmental Engineering
Poster Title: Polymer-Carbon Composite for Wearable Transcutaneous CO₂ Sensor

Doctoral Student Poster Awards

Authors: Revati Kadolkar, Vikash Kumar, Venkatesh Srinivasan, Sanjeev Kumar Ujjain, Dr. Douglas Frey, Dr. Govind Rao
Department: Chemical, Biochemical and Environmental Engineering
Poster Title: Development of a Novel Analytical Sensor Utilizing Ni-NTA and His-tag Affinity for At-Line Quantitative Analysis of Binding Proteins

Honorable Mention – Student Poster Awards

Authors: Alexander G. Doan, Matthew S. Quintanilla, Jessica E. Schafer, Casey M. Douglas, Meredith E. Morse, Dela-Joshua K. Dayie, Kay T. Latt, Julianna C. Wasiuta, Steven D. Harris, and Dr. Mark R. Marten
Department: Chemical, Biochemical and Environmental Engineering
Poster Title: Crosstalk Between Aspergillus nidulans CWIS and SIN Pathways Under Cell Wall Stress

Authors: Amir Babaei Gharehbagh, Rose Taylor, Joy Kiguru, Alyssa M. Burns, Ann Marie G. Carlton, and Dr. Christopher J. Hennigan
Department: Chemical, Biochemical and Environmental Engineering
Poster Title: Effects of Inorganic Salts and pH on the Gas-Aqueous Partitioning of Formic Acid and Acetic Acid

Authors: Elias Gilotte, Chad Sundberg, Hasib Hasan, and Dr. Govind Rao
Department: Chemical, Biochemical and Environmental Engineering
Poster Title: Developing an Online ATP Sensor for Cell-Free Protein Synthesis Monitoring

Judges

Thank you to the Research Day Poster Judges for all their help review of posters, specifically,
Jorge Almodovar (CBEE).

Watch: A recap of URCAD 2024

UMBC’s Undergraduate Research and Creative Achievement Day (URCAD) returned earlier this month for its 28th year, bringing together more than 400 student presenters and the broader university community for a day filled with posters, performances, demonstrations, and much more. 

With excitement and energy in the air of the University Center, undergraduate students—many accompanied by faculty mentors—presented a broad range of research and creative projects to peers, family, friends, and inquiring minds of all kinds. The day included a film festival, interactive video game demonstrations, musical performances, a photography and painting exhibition, as well as poster board and oral presentations from students across colleges. 

Among this year’s group of presenters was Chiad Onyeje ’24, chemical engineering, who explained the research he’s worked on for nearly three years to develop “spherical shells that we can use as internal Band-Aids” he said in this URCAD 2024 recap video. 

“URCAD is different from any other presentations that I’ve been able to give on my research thus far. It really felt like a celebration in comparison,” said Onyeje. “I could go in, have a good time, talk about my research to interested parties, and share why I love this project so much—because it can help people.”

Congratulations to all CBEE students who participated in the URCAD 2024!

Read more about all CBEE participants: https://my3.my.umbc.edu/groups/cbee/posts/141053

Career Connectors: 

On April 10, 2024, hundreds of research posters, oral presentations, dance performances, films, interactive games, and much more were hosted in the University Center and other venues around campus, all presented by UMBC’s undergraduate students. 

Congratulations to all CBEE students who participated in the event!

Alvin Bett | Influence of Solution PH On PFAS Accumulation in a Novel Equilibrium Passive Sampler | Lee Blaney | Chemical, Biochemical, and Environmental Engineering

An Dang | Phosphate Recovery By Donnan Dialysis: Impact of Operating Parameters in a Batch-Recycle Reactor | Lee Blaney | Chemical, Biochemical, and Environmental Engineering

Casey Douglas | Phenotypic Characterization of an Aspergillus Nidulans ∆mpkA∆hogA Strain | Mark R. Marten | Chemical, Biochemical, and Environmental Engineering

Evalynn Ellison | A Synthetic Data Generator to Accelerate Machine Learning Algorithm Development | Brandon DeKosky | Massachusetts Institute of Technology

Elias Gilotte | Online ATP Monitoring in Cell-Free Protein Synthesis | Govind Rao | Chemical, Biochemical, and Environmental Engineering

Garrett Hill | Phenotypic Characterization of Aspergillus Nidulans Protein Kinase PrkA | Mark Marten | Chemical, Biochemical, and Environmental Engineering

Raey Hunde | Advancing In Vitro Tissue Models: The Development of an Innovative High Throughput Model of the Colon | Erin Lavik | Chemical, Biochemical, and Environmental Engineering

Terra Miley | Genetically Encoded Fluorescent Magnesium Sensor to be Used in an Industrial Cell-Free Bioreactor | Govind Rao | Chemical, Biochemical, and Environmental Engineering

Meredith Morse | Characterizing the Aspergillus Nidulans Kinase Deletion Library For Septation in Response to Cell Wall Stress | Mark Marten | Chemical, Biochemical, and Environmental Engineering

Chiad Onyeje | Verification of Hemostatic Nanocapsules Through Rotational Thromboelastometry Analysis | Erin Lavik | Chemical, Biochemical, and Environmental Engineering

Tatiana Perez | Phenotypic Characterization of the Aspergillus Nidulans Double-deletion Mutant ΔmpkAΔnrc2 \ Mark Marten | Chemical, Biochemical, and Environmental Engineering

Matthew Quintanilla | High Throughput Screens to Discover Uncharacterized Cell Wall Signaling Kinases in Aspergillus Nidulans | Mark Marten | Chemical, Biochemical, and Environmental Engineering

Andrea Sequeira | Characterization of ΔmpkAΔsnf1 Double Deletion Strain in Aspergillus Nidulans | Mark Marten | Chemical, Biochemical, and Environmental Engineering

Excerpt from:

Machine Learning for Bioprocess Sensor Innovation

By Gareth John Macdonald - January 31, 2024

Machine learning (ML) could allow drug firms to create predictive process models that optimize development, production, and quality control. But, before embracing ML on the factory floor, manufacturers will need data to “train” the computer algorithms that drive the approach. And this means having process sensors sophisticated enough to track multiple parameters in real-time in highly complex cell cultures according to an industry expert.

Machine learning is a specialized form of artificial intelligence in which computer programs learn to solve tasks or understand the dynamics of complex systems with minimal or no direction. The process is iterative, and the solutions improve over time as more data is introduced.

This need for training data is driving innovation in process sensors, says Govind Rao, PhD, who is director of the Center for Advanced Sensor Technology at the University of Maryland, Baltimore County.

“At the end of the day, AI/ML tools will allow for process monitoring to be simplified once data are generated at scale to relate process conditions to critical quality attributes. The need to run QC tests on quarantined bulk drug substance will be greatly reduced,” he explains. “However, to get there will require high-density process monitoring to allow ML/AI algorithms to relate process conditions to off-line measurements such as glycosylation, aggregation, etc.”

Read full article