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CBEE faculty and students are highlighted for their innovative and impactful work in the areas of 'Climate and Environment' and 'Health and Life Sciences' in the inaugural issue of Inquiring Minds: UMBC Research and Creative Achievement. 

Front Page (bottom right)

Matthew Stromberg, Environmental Engineering PhD student, under the guidance of advisors Dr. Upal Ghosh, professor of chemical, biochemical and environmental engineering and Dr. Yonathan Zohar, professor of marine biotechnology.

Global Leadership in Sustainable Aquaculture Research - Page 1

Matthew Stromberg's work with Dr. Yonathan Zohar, professor of marine biotechnology, on land-based aquaculture is highlighted. Dr. Zohar has been a driving force behind decades of research into land-based aquaculture, which has taken off in the U.S. and abroad in recent years. These operations produce fish for human consumption in land-based facilities that are less susceptible to disease and result in fresher fish for locals. They also remove the risk of releasing waste or farmed fish into the environment and reduce costs and the carbon footprint associated with shipping. Plus, they create jobs and help decrease American reliance on seafood imports.

Centering Communities in Climate Action - Page 3

Dr. Claire Welty, professor of chemical, biochemical and environmental engineering, is featured for her leadership role in the Baltimore Social-Environmental Collaborative (BSEC), a project funded by the U.S. Department of Energy to address urban environmental challenges. Welty and her UMBC colleagues received $2.3 million of the $24.5 million grant awarded to the BSEC. The project aims to generate solutions to environmental concerns through community engagement and collaboration with organizations in three American cities. The team brings decades of experience in environmental monitoring and has received awards from the U.S. Forest Service and the National Science Foundation to support their work. Welty emphasizes the importance of partnering with local communities to address their needs and concerns and finding effective ways to implement solutions. She describes the project as a giant puzzle to put together and looks forward to seeing how it all unfolds.

Developing Nanoparticles That Stop Internal Bleeding - Page 17

The groundbreaking work conducted by Dr. Erin Lavik, professor of chemical, biochemical and environmental engineering and Dr. Nuzhat Maisha, Ph.D. '21, chemical and biochemical engineering and colleagues to develop nanoparticles that can stop internal bleeding is highlighted in the story on page 17. 

The article discusses the challenges of controlling bleeding in trauma patients and the need for faster delivery of medication to control the bleeding. The researchers developed a novel approach to modifying the surfaces of nanoparticles used in lifesaving medications to provide infusions that can be delivered more quickly and with a reduced risk of negative reactions.

The article goes into detail about the researchers' findings and how they focused on the core material of the nanoparticles to reduce infusion reactions, which limit the treatments available to patients. The article also discusses how this groundbreaking research lays the groundwork for future testing of preclinical models using nanocapsules to stop internal bleeding.

Read full articles:  Inquiring Minds: UMBC Research and Creative Achievement. 

Dr. Rao's idea 'Medicines on Demand' advanced to the first round in the ARPA-H Dash to Accelerate Health Outcomes. 

Read the new paper about this idea : https://www.sciencedirect.com/science/article/pii/S1871678423000183

We encourage you to continue to participate in the Dash by voting for your favorite submissions on Polyplexus.

HOW TO VOTE & SUPPORT DR. RAO'S RESEARCH:

A new way to make a virus-fighting protein could save lives during the next pandemic 

The quick and portable production process, described in a newly accepted paper in the journal New Biotechnology, could be easily deployed at the source of a future virus outbreak

A multidisciplinary research team has produced a promising virus-fighting protein using a quick, portable process that could be easily deployed at the source of a future virus outbreak. The team includes researchers from the University of Maryland, Baltimore County (UMBC), Stanford University, the National Cancer Institute (NCI) and the National Center for Advanced Translational Science. The research has been accepted for publication in the journal New Biotechnology.

Griffithsin is a protein originally isolated from red algae. More than a decade ago, researchers in the Molecular Targets Program of the NCI discovered it could protect cells from the HIV virus and it is now in Phase 1 clinical trials in humans. Griffithsin sticks to the surface glycoproteins of certain viruses, making it difficult for the virus to enter host cells. (Glycoproteins are proteins with sugar molecules on them.)

“It’s like taking clay and sticking it to the prongs of an electrical plug to prevent it from entering a socket,” says Govind Rao, a professor of chemical and biochemical engineering at UMBC who is one of the lead researchers on the project. The protein disables a wide range of viruses, including the virus that causes COVID-19.

Medicines that are made with biological molecules like griffithsin are called biologics. They are normally manufactured in huge batches using living cells such as E.coli bacteria. (The cells are given DNA-encoded instructions for how to make the medicine.) However, that method has drawbacks, including the need to keep the cells alive. 

Rao and his colleagues developed a method to manufacture griffithsin that does not require living cells. Instead, the researchers take the protein-manufacturing “guts” out of the cells. Into this soup of cellular components, they then add the DNA instructions for making griffithsin, along with the needed molecular building blocks. 

“The cellular machinery still works, even without a living cell to support it,” says Rao. “The method is simple and effective.”

Using cell-free manufacturing methods, the researchers produced significant quantities of griffithsin in less than 24 hours. They purified the protein to strict standards and demonstrated in lab experiments that it could disable both HIV and SARS-CoV-2 virusesas effectively as the same griffithsin protein made by living cells.

The researchers envision that the method could be quickly deployed to make antiviral medicine at the origin of disease outbreaks. The method could be easily adapted to work with a portable, suitcase-sized biologics manufacturing device, dubbed Bio-MOD, that Rao and a team of mostly UMBC researchers recently developed. They described the device in a 2018 paper in the journal Nature Biomedical Engineering.

The new griffithsin protein manufacturing process together with the portable Bio-MOD device could be a powerful weapon to quickly combat new viruses before they spread.

read full article: https://www.eurekalert.org/news-releases/985854

ENCH 333: CHEMICAL ENGINEERING SEMINAR:PHARMA CAREERS AND DRUG DEVELOPMENT

MONDAYS 5:00 PM-6:30 PM

Excerpt from ''AI scientist' brings us a step closer to the age of machine-generated scientific discovery"

FULL ARTICLE & PODCAST : 

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How To Develop Safe And Effective Medications | Exploring The Next Generation Of Therapeutics

What will the next generation of medicine production look like? Dr. Govind Rao is a Professor of Chemical and Biochemical Engineering, and the Director of the Center for Advanced Sensor Technology at the University of Maryland Baltimore County (UMBC) joins us today to discuss the importance of constructing safe and effective medications – standards that are harder to reach than one may think…

Listen to Govind Rao here: bit.ly/3KdhTr7

Episode also available on Apple Podcasts: apple.co/30PvU9C