Celebrating our CBEE students at the GEARS (Graduate Experience, Achievements & Research Symposium) 2024. Sahar Souizi, Environmental Engineering PhD student in Dr. Blaney’s Lab, clinched the runner-up title, and Revati Kadolkar, Chemical and Biochemical Engineering PhD, under Dr. Frey & CAST, seized the People's Choice Award. 

Congratulations Sahar and Revati, for your outstanding achievements!

GEARS provides a platform for students to showcase their creative achievements, present research accomplishments, and share their experiences with peers. GEARS aims to provide a friendly atmosphere to promote collaboration, improve communication skills, and celebrate the hard work of UMBC graduate students.

Hundreds of East Coast chemical engineering students to gather at UMBC for regional conference

 By: Catherine Meyers | Published: Mar 29, 2024 | UMBC NEWS

Over the weekend of April 6 – 7, the UMBC student chapter of the American Institute of Chemical Engineers (AIChE) will host the 2024 Mid-Atlantic Regional Conference on campus. The event will feature workshops, research presentations, and a career fair with companies such as AstraZeneca and Astek Diagnostics and schools including Johns Hopkins University, Rutgers University, the University of Delaware, and Lehigh University. It will also feature the conferences’ two signature competitive events: Chemical Engineering Jeopardy and ChemE Car—a competition to build and operate a car powered and stopped by chemical reactions.

Organizers expect more than 350 attendees from more than 30 universities across the region. UMBC students are encouraged to register to attend, even if they aren’t chemical engineering majors. “As the premier student chemical engineering conference in the region, this event will offer great opportunities for networking, presenting research, landing internships and jobs, and general professional development,” says Terra Miley ’25, chemical engineering, who is serving as the communications chair for the student organizing committee.

Photo credit: The UMBC campus will host hundreds of chemical engineering students in early April for a regional meeting of the American Institute of Chemical Engineers. (Marlayna Demond ’11/UMBC)

Evalynn Ellison, ‘25 chemical engineering, secured the title of top junior presenter in the engineering, physics, and mathematics category for presenting the poster based on her summer research project titled, "In-Frame Cloning of Chimeric Antigen Receptors to Improve Cancer Therapeutic Discovery" at the Annual Biomedical Research Conference for Minority Students (ABRCMS) conference held in November 2023.

Poster title: In-Frame Cloning of Chimeric Antigen Receptors to Improve Cancer Therapeutic Discovery 

Authors: Evalynn Ellison (1), Azady Pirhanov (2,3), and Brandon DeKosky (2,3)

¹Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County (UMBC)

²Department of Chemical Engineering, Massachusetts Institute of Technology (MIT)

³The Ragon Institute of MGH, MIT, and Harvard

Abstract: Chimeric Antigen Receptors (CARs) are being used to create promising cancer immunotherapies; however, high-throughput CAR discovery remains a challenge due to the many possible proteins that must be screened for activity. In particular, creating very large and diverse CAR gene libraries for effective CAR discovery has been a limitation. This research project focused on developing and optimizing a system to identify productively inserted CAR genes after cloning into expression vectors. To accomplish this, we developed a high-throughput in-frame CAR clone identification strategy based on a fluorescent protein mCherry assay. The changes in fluorescent reporter mCherry expression levels would signal that a potential CAR was expressed in-frame. After cloning test genes, samples were analyzed by flow cytometry to measure the level of fluorescence and percentage of cells expressing fluorescent protein mCherry. We concluded that the designed mCherry-based fluorescent reporter system was sensitive and specific, making it a successful validator of cloned CAR genes. These CAR platforms can be used for cancer therapeutic discovery toward cell-based immunotherapies, such as CAR-Ts. Our new approach to identify CAR candidates will make therapeutic development more streamlined and efficient. 

Photo credit: Evalynn Ellison

CHECK meetings are group sessions for pre-chemical engineering students led by a CBEE faculty member.

These meetings supplement the one-on-one advising session with a COEIT Advisor to receive advising clearance. They are not a replacement for the one on one advising session.

During the CHECK meeting students will :

• connect about important topics regarding course selection and curriculum requirements specific to Chemical Engineering
• gain insider knowledge about the best timing of classes and prerequisites
• discuss updates about electives courses

SIGN UP NOW for your CHECK MEETING

Are you a CBEE Alumni? Stay connected via Linkedin

Low-Cost Technology Cleans Up Contaminated Sites

An innovative technology, developed with funding from the NIEHS Superfund Research Program (SRP), can deliver amendments that immobilize and degrade polychlorinated biphenyls (PCBs) in aquatic environments. The technology has proven effective in the field and resulted in millions of dollars in estimated cost savings at cleanup sites.

The Problem:

PCBs are a large and complex group of chemicals that were used in insulation, coolants, and electrical equipment. Although commercial production of PCBs was banned in the United States in 1979, they persist in the environment because of their stable chemical structure. PCBs can also accumulate in the aquatic food web, where they can pose a threat to human health.

SRP Solutions:

SediMite, developed by Upal Ghosh, Ph.D., of the University of Maryland, Baltimore County, and collaborators, uses activated carbon in the form of specialized pellets to bind to PCBs and reduce their bioavailability, or uptake by fish and other aquatic organisms. The technology can also be combined with microbes that break down PCBs, reducing their toxicity.

Documenting Effectiveness in the Field

• The approach reduces PCBs in sediment porewater and surface water in the field
• The technology lowers PCB levels measured in lake fish

Ghosh and his team collaborated with the Delaware Department of Natural Resources and Environmental Control (DNREC) to use the technology at Mirror Lake. They demonstrated that between 2013 and 2018, PCB concentrations in sediment porewater decreased by about 80% after applying SediMite. They also measured a 70% reduction in PCB levels in the lake’s fish.

Their success has important implications for human health because PCB contamination is the primary reason that fish consumption advisories are issued by DNREC and the Delaware Division of Public Health.

Building on this achievement, DNREC used an enhanced version of the SediMite technology in a new project to reduce PBCs in the Christina River. Ghosh and colleague Kevin Sowers, Ph.D., combined the activated carbon with microorganisms that can break down PCBs to both immobilize PCBs in the sediment and degrade them over time. After five months, SediMite enhanced with PCB-degrading microbes reduced the amount of PCBs in the sediment by approximately 25%. PCB concentrations decreased by around 35% in the surface water and 64% in sediment porewater.

Videos developed by DNREC depict the successes at Mirror Lake and the Christina River projects.

Building the Foundation

• Activated carbon reduces PCB bioavailability in the lab
• The technology offers significant cost savings compared to other clean-up methods

The technology builds on years of research by Ghosh and colleagues. SediMite was initially developed in part with SRP funding in an early project focused on optimizing the delivery method to apply activated carbon pellets to contaminated sites.

Ghosh had previously collaborated with Richard Luthy, Ph.D., an SRP grant recipient at Stanford University, to develop the novel concept of amending sediments with sorbents to reduce pollutant bioavailability. Their initial studies resulted in a method, patented in 2006, to stabilize persistent organic contaminants using carbon as sorbents and laid much of the groundwork for identifying potential barriers and future research needs to make the technology a viable reality, including the need for efficient methods to deliver the sorbents to sediment.

Ghosh then collaborated with Charlie Menzie, Ph.D., to develop SediMite to efficiently deliver amendments to sediments through a U.S. EPA Small Business Innovation Research program grant. Initial tests demonstrated that it was a feasible technology for use in the field. With SRP funding, the researchers scaled up their method to deliver activated carbon pellets from the lab to the field and patented SediMite in 2010.

Ghosh continued his research in a second SRP-funded project aimed at evaluating whether fish uptake less PCBs after remediation with activated carbon. The team used lab studies and modeling approaches to demonstrate that fish can reduced their PCB uptake by as much as 87% after 90 days of treatment with activated carbon.

They also showed that SediMite decreased the assimilation efficiency of PCBs by up to 93%. Assimilation efficiency measures the amount of the contaminant that remains in the body compared to the amount that is excreted. This early work by the scientists included scaling up their remediation work to the field study at Mirror Lake.

The technology was implemented in full-scale to remediate a five-acre lake in Dover, Delaware in 2013. It was also selected as a component of the cleanup strategy for a contaminated sediment site in Middle River, Maryland, where the approach was estimated to cost approximately $22 million less than traditional methods, such as dredging and hauling. 

Optimizing for Use at Scale

• Scaling up bacteria growth, dispersal, and deployment.
• Demonstrating effectiveness in the field.
• Collaborating in full-scale remediation projects.

While developing and patenting SediMite, the researchers identified some limitations to large-scale application of the technology. To address these limitations, Ghosh and Sowers, in collaboration with environmental scientist Bennett Amos, founded RemBac Environmental to enhance the SediMite carbon pellets with PCB-degrading microorganisms. Rembac was funded in 2020 through an SRP small business grant.

In the first phase of their project, they tested methods to optimize growing and storing large volumes of PCB-degrading organisms over time. They also developed and tested methods to apply the microbes more uniformly and cost-effectively to high volumes of activated carbon pellets, enabling them to scale up their technology to broader commercial use.

In the second phase of their project, the team plans to field test the effectiveness and utility of their technology at the New Bedford Harbor Superfund site. They hope their findings will inform regulators and other stakeholders as different PCB clean-up strategies are considered.

In 2022, the Elizabeth River Project started using SediMite to remediate Paradise Creek, a 14-acre tributary to the Elizabeth River in Virginia that is contaminated with PCBs. Another full-scale project, led by EPA, is using SediMite to remove dioxin from sediments in the Scanlon Reservoir in Minnesota.

SRP Funding Creates Synergy

New Directions

In 2021, Ghosh and team were awarded a four-year SRP grant to develop carbon-based sorbent materials to enhance the ability of bacteria to break down PCBs in sediments and mixtures of tetrachloroethylene (PCE) and trichloroethylene (TCE) in groundwater. PCE and TCE are chemicals often used in manufacturing and are the most frequently detected volatile organic chemicals in groundwater.

By understanding the interaction between surface chemistry and microbial degradation, the team expects to develop new technologies to remediate PCBs, PCE, TCE, and other chlorinated contaminants often found in the environment.

link to full article: 

https://www.niehs.nih.gov/research/supported/centers/srp/phi/archives/remediation/sedimite

Summer 2023 

Hennigan Lab

Developing new methods to measure atmospheric gas-phase ammonia

I am excited to deploy the instrumentation that we have been working on to collect data. It will be satisfying to see real tangible results come from something that I have worked on with other students!

The best part of my research is the people I work with, everybody in the lab is excited to be here and work on their respective projects.

Search for faculty and read about their research through their website or their department website. Then send an email to a professor who does research that speaks to you and/or aligns with your career goals.

AIChE ChemE Car Team Lead

Industry or M.S. in Chemical Engineering

https://www.linkedin.com/in/ben-welling-352602248/ 

We are now accepting applications for the third cohort of the BEMORE REU program at UMBC. 

Application Deadline:

For best consideration, please submit your applications by March 1, 2024.

The BEMORE REU program prepares students to address knowledge gaps, develop new technologies, and bring unique perspectives to complex problems in biochemical and environmental engineering and science.

Students that join the BEMORE REU Site will gain the interdisciplinary knowledge, skills, and training to address a variety of grand challenges.

Research Topics: 

•  water pollution & treatment
• sustainable plastic replacements
• smart polymers
• urban air quality
• novel biomaterials
• sustainable batteries and more. 

Additional details are available at https://bemore.umbc.edu/

Program details:

• June 3, 2024 to August 9, 2024
• $6000 stipend, travel allowance, and free on-campus housing
• Access to state-of-the-art laboratories
• Work with a diverse team of faculty and other students
• Learn about current issues in biochemical and environmental engineering and science
• Enjoy field trips, group activities, and our awards banquet

Eligibility:

• All majors are welcome to apply
• Current student at a two- or four-year college or university
• US citizen or permanent resident

APPLY NOW

Questions can be sent to  bemorereu@umbc.edu

Paul Loberg, '24 Chemical Engineering - Biotechnology & Bioengineering Track

Where was your Internship?

USALCO in Baltimore, Maryland

What is the focus of your Internship?

The focus of my internship was to develop an economical way to produce dry aluminum chloralhydrate. I am helping design and conduct experiments which would be used to advance the current R&D project through the pilot phase to a scaled up industrial version. I also did lab work to prepare and test the samples we collected from the experiments.

What are you looking forward to the most about your Internship? 

I am looking forward to returning in the winter and seeing how the project has progressed and working on it further.

What was the best part of your Internship?

The best part of my internship was the level of autonomy I was given, as an intern, by my bosses and co-workers. We had a voice during all discussions, we could make designs and sketches independently, and give our personal feedback on the project and the direction we thought it should move.

What advice do you have for students who are interested in getting involved in research or an internship?

My advice would be, even if it's late in the spring and you haven't managed to find an internship, keep applying to postings you want. I got the text for an interview during finals week while I was taking my last exam. Definitely start applying earlier if you can but don't let rejections or a lack of responses stop you.

Are you a member of any clubs/campus organizations?

I am the Treasurer of UMBC's student chapter of AIChE as well as a member of the Chemical Engineering Jeopardy team. I play basketball for the intramural CBEE team formed by ChemE students.

What are your goals after graduation?

I want to do R&D or process engineering full time.

Yoonjin Cho,

‘24 chemical engineering at Chung-Ang University, South Korea

When did you do your Internship?

Summer 2023

Where was your Internship?

Blaney Lab, UMBC

What is the focus of your Internship?

We are working to develop sampling methods for certain PFAS compounds. This is necessary as governments and regulatory agencies are actively evaluating and implementing measures to restrict the use of certain PFAS compounds and set acceptable exposure limits.

Specifically, I am working on the following projects: 

-Detection of per- and polyfluoroalkyl substances (PFAS) in wastewater, and biosolids samples. 

-Researching the impact of solution pH, temperature, and salt concentration on KPFAS Cl using membranes for passive sampler 

What are you looking forward to the most about your Internship? 

I look forward to improving my ability to read papers effectively and efficiently, as well as gaining practical experience in a laboratory setting and enhancing my data analysis skills.

What was the best part of your Internship OR What was the biggest learning moment of your Internship ?

I gave a presentation about the calibration curve and internal standard during a group meeting. At first, it was challenging to understand the concept, but through the process of looking things up in English and asking questions to team mates, it became fulfilling. Additionally, presenting in front of my colleagues in the lab pushed me out of my comfort zone. 

What advice do you have for students who are interested in getting involved in research or an internship?

Use diverse sources, including not only academic papers but also platforms like YouTube and blogs, to gain an understanding of the topic you're interested in.

Take your time looking for fields you would like but don't hesitate to take action!

Are you a member of any clubs/campus organizations?

University of Maryland-Baltimore County(exchange student)

Chung-Ang University, Korea(senior majoring in chemical engineering)

What are your goals after graduation?

Pursuing master's degree